This will be numerous problems if the ASUS Smart Gesture work failed or ASUS TouchPad driver meets error with Windows 10.
And there are six steps you should do to fix your ASUS TouchPad not working issue:
'''1: Check ASUS TouchPad Design'''
'''2: Use ShortCut to Open ASUS Smart Gesture'''
'''3: Check ASUS Smart Gesture Settings'''
'''4: Reset ASUS Smart Gesture'''
'''5: Uninstall ASUS Smart Gesture and Reinstall It'''
'''6: Update ASUS Touchpad Driver'''
You can follow these steps one by one, and here is a tutorial with pictures: https://windows10skill.com/asus-smart-gesture-not-working-windows-10/
Wish this can help.